Our new Clear+ tissue clearing approach is the sole approach that delipidates samples without having modify in morphology and with small impact on structural integrity.
Megatome can be a vibrating microtome designed to segment a wide number of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With substantial blade vibrating frequency and minimized blade deflection, Megatome permits high-throughput tissue sectioning with uniform surface area profile, along with negligible tissue damage and information decline.
Antibodies may well acquire weeks to diffuse by only some millimeters of tissue, which has a steep labeling gradient from area to Main.
Megatome is suitable for precision: the blade vibrates at an increased frequency and larger amplitude range than other microtomes, and encompasses a one of a kind deflection Command system.
SE utilizes a rotational electrical subject to disperse very electromobile molecules (like antibodies or surfactant micelles) all over a porous sample devoid of harmful electrically billed constructions throughout the tissue. This allows 2-four day clearing of intact organs,
Our preformulated EasyIndex Alternative raises and homogenize the refractive index of delipidated tissue samples, rendering them completely clear. This enables gentle penetration into the sample and guarantees the acquisition of higher-resolution, in-focus picture info.
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eFLASH can be a quick tissue labeling strategy that enables for uniform complete-organ staining in 20 rounds of labeling.
The SmartSPIM light-weight sheet microscope delivers unparalleled resolution and acquisition pace all through intact tissue volumes, although its modular design and style lets you update and customize unique elements.
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Leverage the Very clear+ tissue clearing approach, as well as eFLASH and patented stochastic electrotransport systems, to speedily obvious and label complete organs. Essential highlights and characteristics incorporate:
Our novel Defend tissue preservation strategy kinds intramolecular bonds utilizing polyfunctional, adaptable epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.